Warehouse 13 meets Cabin in the Woods
In reply to SeanoftheUndead (msg # 1):
This is a cool idea. You might want to check out Monster of the Week (listed under "Apocalypse World Engine" system on DrivethruRPG, also sometimes listed on sites as a "PbtA" or "Powered By The Apocalypse" system game.) It specifically suggests a "supernatural investigative agency" type of game.
You might also be able to adapt Call of Cthulhu/Delta Green to suit your purposes.
My last suggestion would be to consider Fate Core/Accelerated, which is a generic system that is less crunchy and combat-centric and more storytelling-oriented. You can adapt it to pretty much any setting. The Librarian and the subsequent Librarians TV show are based on a Fate campaign that the creator of the TV movies and TV show ran with friends, and frankly, the concept is very similar to Warehouse 13. To add to the horror aspect, you could add a "Fear" stress track in addition to the normal health and mental ones.